Warsaw

BMBS COST Action BM1406 Ion Channels and Immune Response

SEPTEMBER 24th, 2015

• 8:45 - 9:10 : Activation and gating mechanism of STIM / Orai Channels - Rainer Schindl, University of Linz, Austria
• 9:10 - 9:35 : Mechanisms regulating SOCE : Orai subunit composition and a novel inhibitory STIM2 splice variant Barbara A. Niemeyer, Saarland University, Homburg, Germany
• 9:35 - 10:00 : Regulation of SOCE and Endoplasmic Reticulum Calcium levels by the Sigma1 receptor and its Ligands - Ruth Murrell-Lagnado, University of Sussex, UK.
• 10:00 - 10:25 : Regulation of neutrophil pro-inflammatory functions by Ca2+ signalling - Sabrina Bréchard, University of Luxembourg.

• 11:15 - 11:40 : NLRP3 inflammasome modulation in macrophages by P2X7 receptor, hemichannels and swelling-sensitive channels - Pablo Pelegrín, Instituto Murciano de Hospital Clínico Universitario Virgen de la Arrixaca (IMIBArrixaca), Murcia, Spain.
• 11:40 - 12:05 : Minimal responsive NLRP3 truncated variant - Iva Hafner Bratkovič, National Institute of Chemistry, Ljubljana, Slovenia.
• 12:05 - 12:30 : Human dendritic cell migration requires calcium influx controlled by the calcium-activated K+ channelKCa3.1 - Florence Velge-Roussel, University of Tours, France.

• 14:00 - 14:15 : The P2X7 receptor: an ion channel with a split personality in inflammation and cancer - Francesco Di Virgilio, University of Ferrara, Italy.
• 14:15 - 14:45 : P2X7 receptor mediated control of adaptive immunity in the small intestine ensures host-microbiota mutualism and glucose homeostasis - Fabio Grassi, Institute for Research in Biomedicine, Bellinzona, Switzerland.
• 14:45 - 15:15 : The P2X7 receptor and other ion channels – roles and targets in pancreatic cancer - Ivana Novak, University of Copenhagen, Denmark.

• 15:45 - 16:15 : P2X7 receptor mediates shedding of vesicles from microglia: implications of vesicle release in neurodegeneration and neuroinflammation - Claudia Verderio, CNR Institute of Neuroscience, Milano, Italy.
• 16:15 - 16:45 : Evidence for non-redundant functions of Cav1.2 and Cav1.3 calcium channels in Th2 cell priming and allergic asthma development in vivo - Magali Savignac, Universitè Paul Sabatier, Toulouse, France.
• 16:45 - 17:15 : Restore Purkinje neuron calcium homeostasis to prevent Yo-Ab neuropathology - Manya Schubert, Haukeland University Hospital, Bergen, Norway.

SEPTEMBER 24th, 2015

• 14:15 - 14:30 : Nanobodies that antagonize the ATP-gated P2X7 ion channel are promising anti-inflammatory drugs - Friedrich Koch-Nolte, University Medical Center, Hamburg, Germany.
• 14:30 - 15:00 : Modulation of membrane potential by Proprietary Potassium Ionophores in Breast Cancer Stem Cell Model - Katja Ester, Ruđer Bošković Institute, Zagreb, Croatia.

• 16:00 - 16:30 : Action of clathrodin and oroidin, and their synthetic analogues on voltage-gated potassium channels - Nace Zidar ,University of Ljubljana, Slovenia.
• 16:30 - 17:00 : Tailoring the selectivity of Anuroctoxin for Kv1.3 K+ channels - Gyorgy Panyi, University of Debrecen, Debrecen, Hungary