Dublin

Dublin meeting COST Action no. BM1406
Dublin University
March 8th- 9h 2018
Scientific program

Thursday 8th March
8:30 - 9:00 : Registration and Welcome
9:00 : Welcome Address

Chair : Florence Velge-Roussel Session "Immune cells and cancer"
09:10 - 10:00 : Bendriss-Vermare Nathalie (Fr) "Overview of myeloid cells in cancer"
10:00 - 10:30 : Manoury Bénédicte (Fr) UNC93B1 and the calcium sensor STIM1 : Partners for MHC class I antigen cross presentation.
10:30 - 11:00 : Rubartelli Anna (It) "Human monocytes shift from vesicular to gasdermin D-mediated IL-1² secretion upon multiple TLR stimulation.
11:00 - 11:30 : Break

Chair : Rainer Schinl Session "ion channel in immune cells"
11:30 - 12:00 : Frischauf Irene (Au) Molecular Insights into the Pathophysiology of the Ca2+ Sensing Protein STIM1.
12:00 - 12:20 : Bonhenry Daniel (CZ) Modulation of human CRAC channels : Insight from simulations.
12:20 - 12:40 : Rottoli Elsa (IT) ATP-gated P2X7 receptor as a novel checkpoint molecule in T effector / memory cell function.
12:40 - 13:00 : Tapia-Abellan Ana (SP) Studying NLRP3 conformation associated to auto-inflammation after intracellular K+ efflux.
13:00 - 14:15 : Lunch.

Session "ion channel in immune cells"
14:15 - 14h50 : Schindl Rainer (AU) Calcium and calmodulin regulation of autophagy transcription factors.
14:50 - 15:20 : Jawhari Anass (Fr) Functional architecture of potassium chloride co-transporter KCC.
15:20 - 15:35 : Maciag Filip (PL) Overexpression of Store-Operated Calcium Entry Proteins alters synaptic properties of mouse hippocampal neurons.
15:35 - 16:30 : Break and Posters.
16:30 - 18:30 : Management Meeting
20:00 : Social Dinner

Friday 9th March
Chair : Paul Buchanan "Ion channels and Cancer cells"
09:00 - 9:55 : Barbury William (UK) "Voltage-gated sodium channels: novel targets for cancer therapy?"
09:55 - 10:25 : Novak Idana (DK) - Ion channels in control of pancreatic cell migration.
10:25 - 10:45 : Murrell-Lagnado Ruth (UK) Role of the P2X4 receptor in breast cancer cell invasiveness.
10:45 - 11:10 : Break and posters

Chair : Ivana Novak "Ion channels and Cancer cells 2"
11:10 - 12:00 : Pardo Luis (DE) - Potassium channels in cancer.
12:00 - 12:15 : Gueguinou Maxime (Fr) SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell migration.
12:15 - 12:30 : Durcik Martina (SL) Conformationally restricted clathrodin analogues as voltage-gated potassium channel modulators.
12:30 - 12:45 : Chira Natalia (UK) Dmd gene mutation causes cell-autonomous alterations in macrophages.
12:45 - 14:30 : Lunch

Chair : Ruth Murrell-Lagnado "Models of Cancer Therapies"
14:30 - 15:20 : Szabo Ildiko (IT) Targeting of mitochondrial ion channels as a tool to selectively induce apoptosis in cancer cells.
15:20 - 15:40 : Gorecki Darek (UK) Sustained activation of P2RX7 induces active MMP-2 release with subsequent purinoceptor cleavage and functional inhibition.
15:40 - 16:00 : Nuray Erin (TK) "CD200 mimetics as a new therapeutic approach for metastatic breast carcinoma resistant to conventional treatments".
16:00 - 16:30 : Break and Posters
16:30 - 17:30 : Round table discussions on cancer

Closing remarks.