Graz
Scientific program
Tuesday February 12th 2019
08:30 - 09:00 : Registration09:00 - 09:10 : Welcome (Florence Velge-Roussel and Rainer Schindl)
Chair : Rainer Schindl
09:10 - 09:40 : Christoph Romanin, Regulation of STIM1 and Orai1 function.
09:40 - 10:00 : Ruth Murrell-Lagnado, Regulation of the Orai: STIM by the Sigma1 receptor.
10:00 - 10:25 : Lukasz Majewski, Transgenic mice overexpressing SOCE proteins in the brain.
10:25 - 10:40 : Daniel Bonhenry, Conformational studies of the luminal domain from STIM1 and STIM2.
10:40 - 11:10 : Break.
Chair : Barbara Niemeyer
11:10 - 11:30 : Romana Schober, Sequential activation of STIM1 links Ca2+ with luminal domain unfolding.
11:30 - 12:00 : Juan Rosado, Role of TRPC6 in store-operated Ca2+ entry in breast cancer cells.
12:00 - 12:30 : Klaus Groschner, Photopharmocology of TRCP channels - initial hurdles, insights and advances beyond gadgetry.
12:30 - 14:00 : Lunch
Chair : Francesco Di Virgilio
14:00 - 14:30 : Gyorgy Panyi, Inactivation gating of voltage-gated K+ channels: structural aspects studied by electrophysiology.
14:30 - 14:45 : Jost Ludvig, Non-invasive ion flux measurements as alternative to patch-clamp.
14:45 - 15:15 : Anna Rubartelli, A switch from lysosome- to gasdermin D-mediated IL-1 secretion causes hyperinflammation in the autoinflammatory CAPS disease.
15:15 - 15:30 : Sanja Pekovic, Role of L-type Cav1.2 calcium channels in regulation of neuroinflammation and neuroregeneration after brain injury.
15:30 - 15:45 : Break.
15:45 - 17:00 : MC Meeting and parallel start of poster session.
17:00 - 19:00 : Poster session and wine.
Poster session (presenters) tuesday, february 12th 2019
Sahil Adriouch : P2X7 receptor : a novel therapeutic target in inflammatory diseases and cancer.
Herwig Grabmayr : A novel deletion in the CRAC channel protein STIM1 acts as a remedy for Stormorken syndrome pathology.
Ozlen Konu : Systems biology of cholinergenis receptor nicotinic alpha-5 (CHRNA5) in breast cancer.
Adela Krizova : Characterization of SK3 and Orai1 channel interplay.
Victoria Lunz : Ca2+ dependent, strucutural rearrangements in disease-related STIM1 proteins.
Kinga Majchrzak : Application of magnetic microbeads for activation of T lymphocytes isolated from canine peripheral blood.
Anya Meshcheriakovar : SARAF, a negative regulator of store-operated calcium entry.
Claudia Rodrigues : Aquaporin gene expression in breast cancer cells upon oxidative stress treatment.
Petra Visic : Sigma1 receptor regulation of store-operated Ca2+ entry (SOCE).
Orsolya Vörös : Molecular background or Orai1 accumulation in the immunological synapse.
Nace Zidar : Isoform selective inhibitors of voltage-gated sodium and potassium channels for the treatment of cancer.
Wednesday february 13th 2019
Chair : Irene Frischauf09:00 - 09:30 : Nicolas Demaurex - Store-operated calcium entry during phagocytosis.
09:30 - 10:00 : Ivan Bogeski - Calcium and redox signals are important regulators of immune cell physiology.
10:00 - 10:30 : Barbara Niemeyer - Adapting calcium homeostasis to cell-type specific needs.
10:30 - 11:00 : Annette Lis - Orai/STIM signaling in aging.
11:00 - 11:30 : Break.
11:30 - 11:50 : Isaac Jardin-Polo - Role of EFHB, a novel modulator of store-operated Ca2+ entry in breast cancer cells.
11:50 - 12:05 : Lucile Noyer - Orai/NFAT pathway is a gatekeeper of cancer stem cell quiescent/activation transition.
12:05 - 12:20 : Darek Gorecki - Dystrophic mdx mouse myoblasts exhibit elevated ATP/UTP-evoked metabotropic purinergic responses and alterations in calcium signalling.
12:20 - 12:35 : Fritz Nolte - Immunomoldulation with P2X7-targeting biologics
12:35 - 14:00 : Lunch
Chair : Ruth Murrell-Lagnado
14:00 - 14:30 : Eitan Reuveny - SARAF as a modulator of SOCE activity.
14:30 - 15:00 : Wolfgang Graier - Mitochondria - endoplasmic reticulum crosstalk as therapeutic target against aging, cancer and diabetes.
15:30 - 16:00 : Andreas Guse - Orai1, STIM1/2 and dyanodine receptor type 1 shape sub-second Ca2+ microdomains upon T-cell activation
16:00 - 16:15 : Isabella Derler - Insights in Orai1 signal propagation.
16:15 - 16:30 : Niroj Shrista - TRICA associates with the junctionnal STIM/Orai complex to limit the frequency of oscillatory Ca2+ signals.
16:30 - 17:00 : Break.
Chair: Christoph Romanin
17:00 - 18:00 : Anant Parekh - CRAC channel-transcription coupling
19:00 : Convivial dinner Gasthaus Lendplatzl.
Thursday February 14th 2019
Chair : Romana Schober09:00 - 09:30 : Elena Pohl - Phosphatidylethanolamine mediates reactive aldehyde's action on uncoupling proteins
Young scientists scientific session
09:30 - 09:45 : Iga Wasilewska - Identification of zebrafish toolkit genes and their expression in the brain
09: 45 - 10:00 : Rishikesh Kumar Gupta - and decoding of Ca2+ oscillations in zebrafish brain neurons by in vivo Ca2+ imaging
10:00 - 10:15 : Oksana Palchevska - Zebrafish as a model for Ca2+ signaling studies in vitro
10:15 - 10:30 : Ines Viera Da Silva - Involvement of aquaporins in inflammasome priming and activation.
10:30 - 10:45 : Elena Adinolfi - New insights on the role of P2X7 receptor in tumor associated immune response and regulation of purinergic signaling in the tumor microenvironment.
10:45 - 11:00 : Cristina Alacron-Vila - ATP6gated P2X7 receptor induces the release of CD14 and is crucial for the survival during sepsis.
11:00 : Styrian Brettljause and Departure